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In this work, an analysis has been done to describe the molecular structure, spectroscopic, reduced density gradient, topological properties, atomic charges, Lipinski rule, Natural bond orbital analysis, docking and molecular dynamics simulation of the potent antiviral drug EIDD-2801 in the effective treatment against COVID-19. Intramolecular charge distribution is well understood by three schemes such as AIM, Mulliken and NBO analysis and non-covalent interactions have been understood through reduced density gradient. Topological properties, such as charge density and Laplacian of charge density along with the electron localization function, make it easy to obtain comprehensive information about bond strengths and critical points. The details obtained from the calculation of global reactivity descriptors and Lipinski rule are useful for understanding the nature of molecular reactivity and site selectivity. Electrostatic potentials help to identify potential electrophilic and nucleophilic sites for interaction between EIDD-2801 and target proteins. The molecular docking combined with molecular dynamic simulation studies enables us to get better picture about the ligand-protein interaction.Copyright © 2023 Indian Chemical Society
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Due to various benefits of mindfulness, it is implemented in various fields like medicine, Military. Psychiatry, sports, Education etc. It is clear that various psychologists and researchers have identified different levels of components of mindfulness in different angles in the past chronological 3 decades. It is the need of the hour to rethink the components of mindfulness and to be identified appropriate new components based on the impact of social media in our life and the Covid-19 pandemic situation in all over the world.
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Background: Global outbreak of deadly Corona virus disease has forced health care professionals of various disciplines in Hospital and community setting to use personal protective equipment (PPE) which consists of completely encapsulated suit, led the frontline health care professionals to face not only the physical discomfort but also other health consequences. Aims and Objectives: This study is conducted to assess the physical, physiological, and psychological health consequences faced by health care workers using Level III PPE when attending COVID-19 patients. Materials and Methods: This is a crosssectional study conducted in the month of December 2020 and January 2021 amongst Medicos, Paramedicals, Nurses and other health care professionals in a tertiary care hospital attending COVID-19 duty using an online questionnaire which included sociodemographic profile, frequency of the duty, physical, physiological, psychological difficulties faced while using PPE, and the responses was recorded according to three-point Likert's scale. Data were analyzed using suitable statistical methods with the help of SPSS V.23. Results: A total of227 front line warriors were included in the study with 157 (69%) males, 70 (31%) females among them 121 (53%) medicos, 68 (30%) nurses, 23 (10%) paramedicals, 15 (7%) others. Majority of them that is 186 were in 21-30 years age group, 31 in 31-40 years, 10 in >41 years. 124 (55%) used PPE for 4-6 h, 84 (37%) >6 h and 19 (8%) used for <4 h. Physical symptoms are most commonly faced health consequences followed by psychological and physiological symptoms. Medicos faced more difficulty and regularly in all three health consequences comparing with nurses and others. Conclusion: This study provides insight into various health consequences and difficulties experienced by the health care professionals while on PPE. Surveillance of the physical, physiological and psychological health consequences enroute us to prepare efficiently for future outbreaks worldwide. [ FROM AUTHOR] Copyright of Asian Journal of Medical Sciences is the property of Manipal Colleges of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
ABSTRACT
BACKGROUND AND AIM: The pandemic COVID-19 occurring due to novel emerging coronavirus-2019 (SARS-CoV-2) is severely affecting the worldwide public health, culture, economy and human social behaviour. Till date, there is no approved medicine/treatment to cure COVID-19, whereas, vaccine development efforts are going on high priority. This review aimed to provide an overview of prior art, recent advances, vaccine designing strategies, current scenario, opportunities and challenges related to development of coronavirus vaccine. METHOD: A literature survey was conducted using Scopus, PubMed and Google Scholar with the search key as: coronavirus vaccine, SARS vaccine, MERS vaccine and COVID-19 vaccine. Articles related to above search query were retrieved, sorted, analyzed and developed into an easy-to-understand review. RESULTS: The genome phylogenetic analysis suggested that genomic sequence of SARS-CoV-2 is almost 80% similar to that of SARS-CoV, further both these viruses bind to same host cell receptor ACE-2. Hence it is expected that, previously available literature data about coronavirus vaccine designing may play crucial role in development of rapid vaccine against COVID-19. In view of this, the present review discuss (i) existing information (from 2003 to present) about the type of vaccine, antigen, immunogenic response, animal model, route of administration, adjuvants and current scenario for designing of coronavirus vaccine (ii) potential factors and challenges related to rapid development of COVID-19 vaccine. CONCLUSION: In conclusion, we discuss possible clues/ target sites for designing of vaccine against SARS-CoV-2 virus based on prior-art.